His father, Ellis Marsalis was pianist and jazz teacher, and his mother was a jazz singer. Three brothers are also jazz musicians.
He has collaborated with musicians such as Miles Davis, Dizzy Gillespie, Herbie Hancock, Bruce Hornsby, Harry Connick, Jr., Sting, and the Grateful Dead.
Was music director of The Tonight Show (with Jay Leno) for 3 years
Has acted in a few movies and television
Won several awards including 3 Grammys with the his father and brothers